Publications

ArticlesPre-PrintsReviewsBook Chapters – Patents

Articles in Peer Reviewed Journals

34. Nicolas Perez-Soto, Oliver Creese, Francisco Fernández-Trillo, and Anne-Marie Krachler. Aggregation of Vibrio cholerae by cationic polymers enhances quorum sensing but over-rides biofilm dissipation in response to autoinduction. ACS Chemical Biology (2018). doi:10.1021/acschembio.8b00815 (biorXiv)

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33. Juan M Priegue, Irene Lostalé-Seijo, Daniel Crisan, Juan R. Granja, Francisco Fernández-Trillo, and Javier Montenegro. Different Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection. Biomacromolecules19 (7), 2638–2649 (2018). doi:10.1021/acs.biomac.8b00252

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32. Insua, I., Petit, M., Blackman, L., Keogh, R., Pitto-Barry, A., O’Reilly, R., Peacock, A., Krachler, A.-M. & Fernandez-Trillo, F. Structural determinants of the stability of enzyme‐responsive polyion complex (PIC) nanoparticles targeting Pseudomonas aeruginosa’s elastase. ChemNanoMat. 8, 807-814. doi: 10.1002/cnma.201800054 (2018).

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31. O’Donoghue, E. et al. Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells. Plos Pathog 13, e1006760 (2017).

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30. Kolodziej, A., Figueiredo, M., Koper, M., Fernandez-Trillo, F. & Rodriguez, P. Phosphate-mediated electrochemical adsorption of cisplatin on gold electrodesElectrochimica Acta 248, 409–415 (2017).

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29. Blanco-Fernandez, B., Concheiro, A., Makwana, H., Fernandez-Trillo, F., Alexander, C. & Alvarez-Lorenzo, C. (2017). Dually sensitive dextran-based micelles for methotrexate delivery. RSC Advances 7(24), 14448–14460.

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28. I. Insua, L. Zizmare, A. F. A. F. Peacock, A. M. Krachler, and F. Fernandez-Trillo, Polymyxin B containing polyion complex (PIC) nanoparticles: Improving the antimicrobial activity by tailoring the degree of polymerisation of the inert component. Sci Rep, 2017, 7, 9396I.

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27. Kolodziej, A., Fernandez-Trillo, F. & Rodriguez, P. Determining the parameters governing the electrochemical stability of thiols and disulfides self-assembled monolayer on gold electrodes in physiological medium. J Electroanal Chem (2017). doi:10.1016/j.jelechem.2017.07.039

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26. D. Crisan, O. Creese, R. Ball, J. L. Brioso, Ben Martyn, J. Montenegro and F. Fernandez-Trillo, Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification. Polym. Chem., 2017, doi: 10.1039–C7PY00535K..

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25. E. P. Magennis, N. Francini, F. Mastrotto, R. Catania, M. Redhead, F. Fernandez-Trillo, D. Bradshaw, D. Churchley, K. Winzer, C. Alexander and G. Mantovani, Polymers for binding of the gram-positive oral pathogen Streptococcus mutans. PLoS ONE, 2017, 12, e0180087.

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24. N. Perez-Soto, L. Moule, D. Crisan, I. Insua, L. Taylor-Smith, K. Voelz, A. M. Krachler and F. Fernandez-Trillo, Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in Vibrio cholerae and downregulate the expression of virulence genes. Chem Sci. 8, 5291-5298. (2017), doi: 10.1039/C7SC00615B. (biorXiv)

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23. I. Insua, S. Majok, A. F. A. Peacock, A. M. Krachler, F. Fernandez-Trillo, Preparation and antimicrobial evaluation of polyion complex (PIC) nanoparticles loaded with polymyxin B, Eur. Polym. J. (2017), 87, 478-486. – (UoB Repository)

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22. E. Leire et al., Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability. Biomater. Sci. (2016), 4, 998-1006. – (UoB repository)

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21. J. M. Priegue et al., In Situ Functionalized Polymers for siRNA Delivery. Angew. Chem., Int. Ed. (2016), 55, 7492–7495. – (UoB repository)

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20. I. Insua et al., Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers. Polym. Chem. 7, 2684–2690 (2016). – (UoB repository)

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19. Louzao, I., Sui, C., Winzer, K., Fernandez-Trillo, F., and Alexander, C. (2015) Cationic polymer mediated bacterial clustering: Cell-adhesive properties of homo- and copolymers. Eur. J. Pharm. Biopharm. 95, 47-92 (2015). – (UoB repository)

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18. E Peter Magennis, Francisco Fernandez-Trillo, Cheng Sui, Sebastian G Spain, David J Bradshaw, David Churchley, Giuseppe Mantovani, Klaus Winzer, and Cameron Alexander. Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling. Nat. Mater. 13, 748–755 (2014). – (UoB repository)

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17. Magnusson, J. P., Fernandez-Trillo, F., Sicilia, G., Spain, S. G. & Alexander, C. Programmed assembly of polymer-DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition. Nanoscale 6, 2368–2374 (2014).

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16. Leong T Lui, Xuan Xue, Cheng Sui, Alan Brown, David I Pritchard, Nigel Halliday, Klaus Winzer, Steven M Howdle, Francisco Fernandez-Trillo, Natalio Krasnogor, and Cameron Alexander. Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nat. Chem. 5, 1058–1065 (2013). – (UoB repository)

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15. Sicilia, G., Grainger-Boultby, C., Francini, N., Magnusson, J. P., Saeed, A. O., Fernandez-Trillo, F., Spain, S. G., and Alexander, C. Programmable polymer-DNA hydrogels with dual input and multiscale responses. Biomater. Sci. 2, 203 (2013). – (UoB repository)

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14.- Fowler, R., Vllasaliu, D., Fernández-Trillo, F., Garnett, M., Alexander, C., Horsley, H., Smith, B., Whitcombe, I., Eaton, M. and Stolnik, S. Nanoparticle Transport in Epithelial Cells: Pathway Switching Through Bioconjugation. Small 9, 3282–3294 (2013).

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13.- Cooper, G. J. T., Bowman, R. W, Magennis, E. P., Fernández-Trillo, F., Alexander, C., Padgett, M. J., and Cronin, L. Directed Assembly of Inorganic Polyoxometalate-based Micrometer-Scale Tubular Architectures by Using Optical Control. Angew. Chem., Int. Ed. 51, 12754–12758 (2012).

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12.- Yaşayan, G., Redhead, M., Magnusson, J. P., Spain, S. G., Allen, S., Davies, M. C., Alexander, C., and Fernández-Trillo, F. Well-defined polymeric vesicles with high stability and modulation of cell uptake by a simple coating protocol. Polym. Chem. 3, 2596–2604 (2012).

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11.- Xue, X., Pasparakis, G., Halliday, N., Winzer, K., Howdle, S. M., Cramphorn, C. J., Cameron, N. R., Gardner, P. M., Davis, B. G., Fernández-Trillo, F., and Alexander, C. Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference. Angew. Chem., Int. Ed. 50, 9852–9856 (2011).

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10.- Fernández-Trillo, F., Pacheco-Torres. J., Correa, J., Ballesteros, P., López-Larrubia, P., Cerdán, S., Riguera, R., and Fernández-Megía, E. Dendritic MRI Contrast Agents: An Efficient Prelabeling Approach Based on CuAAC. Biomacromolecules 12, 2902–2907 (2011).

9.- Yaşayan, G., Saeed, A. O., Fernández-Trillo, F., Allen, S., Davies, Martyn C., Jangher, A., Paul, A., Thurecht, K. J., King, S. M., Schweins, R., Griffiths, R., Magnusson, J. P., and Alexander, C. Responsive hybrid block co-polymer conjugates of proteins–controlled architecture to modulate substrate specificity and solution behaviour. Polym. Chem. 2, 1567–1578 (2011).

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8.- Smaldon, J., Romero-Campero, F. J., Fernández-Trillo, F., Gheorghe, M., Alexander, C., and Krasnogor, N. A computational study of liposome logic: towards cellular computing from the bottom up. Syst. Synth. Biol. 4, 157–179 (2010).

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7.- Fernández-Trillo, F., Fernández-Megía, E. and Riguera, R. Evaluation of amino acids as chiral ligands for the enantiodifferentiation of carbohydrates by TOCSY NMR. J. Org. Chem. 75, 3878–3881 (2010).

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6.- Fernández-Trillo, F., van Hest, J. C. M., Thies, J. C., Michon, T., Weberskirch, R., and Cameron, N. R. Reversible Immobilization onto PEG-based Emulsion-templated Porous Polymers by Co-assembly of Stimuli Responsive Polymers. Adv. Mater. 21, 55–59 (2009).

5.- Fernández-Trillo, F., van Hest, J. C. M., Thies, J. C., Michon, T., Weberskirch, R., and Cameron, N. R. Fine-tuning the transition temperature of a stimuli-responsive polymer by a simple blending procedure. Chem. Commun. 2230–2232 (2008).

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4.- Fernández-Trillo, F., Dureault, A., Bayley, J. P. M., van Hest, J. C. M., Thies, J. C., Michon, T., Weberskirch, R., and Cameron, N. R., Elastin-based side-chain polymers: Improved synthesis via RAFT and stimulus responsive behavior. Macromolecules 40, 6094–6099 (2007).

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3.- López, S., Fernández-Trillo, F., Midón, P., Castedo, L. and Saá, C. Synthesis of marine polyacetylenes callyberynes A-C by transition-metal-catalyzed cross-coupling reactions to sp centers. J. Org. Chem. 71, 2802–2810 (2006).

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2.- López, S., Fernández-Trillo, F., Midón, P., Castedo, L. and Saá, C. First stereoselective syntheses of (-)-siphonodiol and (-)-tetrahydrosiphonodiol, bioactive polyacetylenes from marine sponges. J. Org. Chem. 70, 6346–6352 (2005).

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1.- López, S., Fernández-Trillo, F., Castedo, L. and Saá, C. Synthesis of callyberynes A and B, polyacetylenic hydrocarbons from marine sponges. Org. Lett. 5, 3725–3728 (2003).

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Preprints

1.- N. Perez-Soto, L. Moule, D. N. Crisan, I. Insua, L. M. Taylor-Smith, K. Voelz, F. Fernandez-Trillo, A. Krachler, bioRxiv 2016, 066563.

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Reviews

6.- Fernandez-Trillo, F., Grover, L. M., Stephenson-Brown, A., Harrison, P., and Mendes, P. M. (2017) Vesicles in Nature and the Laboratory: Elucidation of Their Biological Properties and Synthesis of Increasingly Complex Synthetic Vesicles. Angew. Chem., Int. Ed. 56, 3142–3160.

5.- Insua, I., Wilkinson, A., and Fernandez-Trillo, F. Polyion complex (PIC) particles: Preparation and biomedical applications. Eur. Polym. J. 81, 198–215 (2016) – (UoB repository) – (PubMed Central)

4.- Monzó, J., Insua, I., Fernandez-Trillo, F., and Rodriguez, P. Fundamentals, achievements and challenges in the electrochemical sensing of pathogens. Analyst, 140, 7116–7128 (2015). – (UoB repository)

3.- Lallana, E., Fernández-Trillo, F., Sousa-Herves, A., Riguera, R. and Fernández-Megía, E. Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery. Pharm. Res. 29, 902–921 (2012).

2.- Lallana, E., Sousa-Herves, A., Fernández-Trillo, F., Riguera, R. and Fernández-Megía, E. Click Chemistry for Drug Delivery Nanosystems. Pharm. Res. 29, 1–34 (2011).

1.- Magnusson, J. P., Saeed, A. O., Fernández-Trillo, F. and Alexander, C. Synthetic polymers for biopharmaceutical delivery. Polym. Chem. 2, 48–59 (2010).

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Book Chapters

1.- Alexander, C. and Fernandez-Trillo, F. Bioresponsive polyplexes and micelleplexes, in Smart Materials for Drug Delivery. Alvarez-Lorenzo, C. and Concheiro, A. Eds, RSC Publishing (2013).

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Patents

1.- Screening Method and Reagents for Transfection and Delivery of Biomolecules, P201531831, filed 17 Dec. 2015.

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