ArticlesPre-PrintsReviewsBook Chapters – Patents

Articles in Peer Reviewed Journals

33. Juan M Priegue, Irene Lostalé-Seijo, Daniel Crisan, Juan R. Granja, Francisco Fernández-Trillo, and Javier Montenegro. Different Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection. Biomacromolecules (2018). doi:10.1021/acs.biomac.8b00252


32. Insua, I., Petit, M., Blackman, L., Keogh, R., Pitto-Barry, A., O’Reilly, R., Peacock, A., Krachler, A.-M. & Fernandez-Trillo, F. Structural determinants of the stability of enzyme‐responsive polyion complex (PIC) nanoparticles targeting Pseudomonas aeruginosa’s elastase. ChemNanoMat. doi: 10.1002/cnma.201800054 (2018).


31. O’Donoghue, E. et al. Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells. Plos Pathog 13, e1006760 (2017).


30. Kolodziej, A., Figueiredo, M., Koper, M., Fernandez-Trillo, F. & Rodriguez, P. Phosphate-mediated electrochemical adsorption of cisplatin on gold electrodesElectrochimica Acta 248, 409–415 (2017).


29. Blanco-Fernandez, B., Concheiro, A., Makwana, H., Fernandez-Trillo, F., Alexander, C. & Alvarez-Lorenzo, C. (2017). Dually sensitive dextran-based micelles for methotrexate delivery. RSC Advances 7(24), 14448–14460.


28. I. Insua, L. Zizmare, A. F. A. F. Peacock, A. M. Krachler, and F. Fernandez-Trillo, Sci Rep, 2017, 7, 9396I. Insua, L. Zizmare, A. F. A. F. Peacock, A. M. Krachler, and F. Fernandez-Trillo, Sci Rep, 2017, 7, 9396.


27. Kolodziej, A., Fernandez-Trillo, F. & Rodriguez, P. Determining the parameters governing the electrochemical stability of thiols and disulfides self-assembled monolayer on gold electrodes in physiological medium. J Electroanal Chem (2017). doi:10.1016/j.jelechem.2017.07.039


26. D. Crisan, O. Creese, R. Ball, J. L. Brioso, Ben Martyn, J. Montenegro and F. Fernandez-Trillo, Polym. Chem., 2017, doi: 10.1039–C7PY00535K..


25. E. P. Magennis, N. Francini, F. Mastrotto, R. Catania, M. Redhead, F. Fernandez-Trillo, D. Bradshaw, D. Churchley, K. Winzer, C. Alexander and G. Mantovani, PLoS ONE, 2017, 12, e0180087.


24. N. Perez-Soto, L. Moule, D. Crisan, I. Insua, L. Taylor-Smith, K. Voelz, A. M. Krachler and F. Fernandez-Trillo, Chem Sci. 2017, doi: 10.1039/C7SC00615B.


23. I. Insua, S. Majok, A. F. A. Peacock, A. M. Krachler, F. Fernandez-Trillo, Preparation and antimicrobial evaluation of polyion complex (PIC) nanoparticles loaded with polymyxin B, Eur. Polym. J. (2017), 87, 478-486. – (UoB Repository)


22. E. Leire et al., Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability. Biomater. Sci. (2016), 4, 998-1006. – (UoB repository)


21. J. M. Priegue et al., In Situ Functionalized Polymers for siRNA Delivery. Angew. Chem., Int. Ed. (2016), 55, 7492–7495. – (UoB repository)


20. I. Insua et al., Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers. Polym. Chem. 7, 2684–2690 (2016). – (UoB repository)

For Web

19. Louzao, I., Sui, C., Winzer, K., Fernandez-Trillo, F., and Alexander, C. (2015) Cationic polymer mediated bacterial clustering: Cell-adhesive properties of homo- and copolymers. Eur. J. Pharm. Biopharm. 95, 47-92 (2015). – (UoB repository)


18. E Peter Magennis, Francisco Fernandez-Trillo, Cheng Sui, Sebastian G Spain, David J Bradshaw, David Churchley, Giuseppe Mantovani, Klaus Winzer, and Cameron Alexander. Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling. Nat. Mater. 13, 748–755 (2014). – (UoB repository)

Figure 1_AS

17. Magnusson, J. P., Fernandez-Trillo, F., Sicilia, G., Spain, S. G. & Alexander, C. Programmed assembly of polymer-DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition. Nanoscale 6, 2368–2374 (2014).


16. Leong T Lui, Xuan Xue, Cheng Sui, Alan Brown, David I Pritchard, Nigel Halliday, Klaus Winzer, Steven M Howdle, Francisco Fernandez-Trillo, Natalio Krasnogor, and Cameron Alexander. Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nat. Chem. 5, 1058–1065 (2013). – (UoB repository)


15. Sicilia, G., Grainger-Boultby, C., Francini, N., Magnusson, J. P., Saeed, A. O., Fernandez-Trillo, F., Spain, S. G., and Alexander, C. Programmable polymer-DNA hydrogels with dual input and multiscale responses. Biomater. Sci. 2, 203 (2013). – (UoB repository)


14.- Fowler, R., Vllasaliu, D., Fernández-Trillo, F., Garnett, M., Alexander, C., Horsley, H., Smith, B., Whitcombe, I., Eaton, M. and Stolnik, S. Nanoparticle Transport in Epithelial Cells: Pathway Switching Through Bioconjugation. Small 9, 3282–3294 (2013).

Figure 1

13.- Cooper, G. J. T., Bowman, R. W, Magennis, E. P., Fernández-Trillo, F., Alexander, C., Padgett, M. J., and Cronin, L. Directed Assembly of Inorganic Polyoxometalate-based Micrometer-Scale Tubular Architectures by Using Optical Control. Angew. Chem., Int. Ed. 51, 12754–12758 (2012).


12.- Yaşayan, G., Redhead, M., Magnusson, J. P., Spain, S. G., Allen, S., Davies, M. C., Alexander, C., and Fernández-Trillo, F. Well-defined polymeric vesicles with high stability and modulation of cell uptake by a simple coating protocol. Polym. Chem. 3, 2596–2604 (2012).


11.- Xue, X., Pasparakis, G., Halliday, N., Winzer, K., Howdle, S. M., Cramphorn, C. J., Cameron, N. R., Gardner, P. M., Davis, B. G., Fernández-Trillo, F., and Alexander, C. Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference. Angew. Chem., Int. Ed. 50, 9852–9856 (2011).


10.- Fernández-Trillo, F., Pacheco-Torres. J., Correa, J., Ballesteros, P., López-Larrubia, P., Cerdán, S., Riguera, R., and Fernández-Megía, E. Dendritic MRI Contrast Agents: An Efficient Prelabeling Approach Based on CuAAC. Biomacromolecules 12, 2902–2907 (2011).

9.- Yaşayan, G., Saeed, A. O., Fernández-Trillo, F., Allen, S., Davies, Martyn C., Jangher, A., Paul, A., Thurecht, K. J., King, S. M., Schweins, R., Griffiths, R., Magnusson, J. P., and Alexander, C. Responsive hybrid block co-polymer conjugates of proteins–controlled architecture to modulate substrate specificity and solution behaviour. Polym. Chem. 2, 1567–1578 (2011).


8.- Smaldon, J., Romero-Campero, F. J., Fernández-Trillo, F., Gheorghe, M., Alexander, C., and Krasnogor, N. A computational study of liposome logic: towards cellular computing from the bottom up. Syst. Synth. Biol. 4, 157–179 (2010).


7.- Fernández-Trillo, F., Fernández-Megía, E. and Riguera, R. Evaluation of amino acids as chiral ligands for the enantiodifferentiation of carbohydrates by TOCSY NMR. J. Org. Chem. 75, 3878–3881 (2010).


6.- Fernández-Trillo, F., van Hest, J. C. M., Thies, J. C., Michon, T., Weberskirch, R., and Cameron, N. R. Reversible Immobilization onto PEG-based Emulsion-templated Porous Polymers by Co-assembly of Stimuli Responsive Polymers. Adv. Mater. 21, 55–59 (2009).

5.- Fernández-Trillo, F., van Hest, J. C. M., Thies, J. C., Michon, T., Weberskirch, R., and Cameron, N. R. Fine-tuning the transition temperature of a stimuli-responsive polymer by a simple blending procedure. Chem. Commun. 2230–2232 (2008).


4.- Fernández-Trillo, F., Dureault, A., Bayley, J. P. M., van Hest, J. C. M., Thies, J. C., Michon, T., Weberskirch, R., and Cameron, N. R., Elastin-based side-chain polymers: Improved synthesis via RAFT and stimulus responsive behavior. Macromolecules 40, 6094–6099 (2007).


3.- López, S., Fernández-Trillo, F., Midón, P., Castedo, L. and Saá, C. Synthesis of marine polyacetylenes callyberynes A-C by transition-metal-catalyzed cross-coupling reactions to sp centers. J. Org. Chem. 71, 2802–2810 (2006).


2.- López, S., Fernández-Trillo, F., Midón, P., Castedo, L. and Saá, C. First stereoselective syntheses of (-)-siphonodiol and (-)-tetrahydrosiphonodiol, bioactive polyacetylenes from marine sponges. J. Org. Chem. 70, 6346–6352 (2005).


1.- López, S., Fernández-Trillo, F., Castedo, L. and Saá, C. Synthesis of callyberynes A and B, polyacetylenic hydrocarbons from marine sponges. Org. Lett. 5, 3725–3728 (2003).


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1.- N. Perez-Soto, L. Moule, D. N. Crisan, I. Insua, L. M. Taylor-Smith, K. Voelz, F. Fernandez-Trillo, A. Krachler, bioRxiv 2016, 066563.

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6.- Fernandez-Trillo, F., Grover, L. M., Stephenson-Brown, A., Harrison, P., and Mendes, P. M. (2017) Vesicles in Nature and the Laboratory: Elucidation of Their Biological Properties and Synthesis of Increasingly Complex Synthetic Vesicles. Angew. Chem., Int. Ed. 56, 3142–3160.

5.- Insua, I., Wilkinson, A., and Fernandez-Trillo, F. Polyion complex (PIC) particles: Preparation and biomedical applications. Eur. Polym. J. 81, 198–215 (2016) – (UoB repository) – (PubMed Central)

4.- Monzó, J., Insua, I., Fernandez-Trillo, F., and Rodriguez, P. Fundamentals, achievements and challenges in the electrochemical sensing of pathogens. Analyst, 140, 7116–7128 (2015). – (UoB repository)

3.- Lallana, E., Fernández-Trillo, F., Sousa-Herves, A., Riguera, R. and Fernández-Megía, E. Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery. Pharm. Res. 29, 902–921 (2012).

2.- Lallana, E., Sousa-Herves, A., Fernández-Trillo, F., Riguera, R. and Fernández-Megía, E. Click Chemistry for Drug Delivery Nanosystems. Pharm. Res. 29, 1–34 (2011).

1.- Magnusson, J. P., Saeed, A. O., Fernández-Trillo, F. and Alexander, C. Synthetic polymers for biopharmaceutical delivery. Polym. Chem. 2, 48–59 (2010).

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Book Chapters

1.- Alexander, C. and Fernandez-Trillo, F. Bioresponsive polyplexes and micelleplexes, in Smart Materials for Drug Delivery. Alvarez-Lorenzo, C. and Concheiro, A. Eds, RSC Publishing (2013).

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1.- Screening Method and Reagents for Transfection and Delivery of Biomolecules, P201531831, filed 17 Dec. 2015.

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